Ketamine PCA for treatment of end-of-life neuropathic pain in pediatrics.
Identifieur interne : 000447 ( Main/Exploration ); précédent : 000446; suivant : 000448Ketamine PCA for treatment of end-of-life neuropathic pain in pediatrics.
Auteurs : Matthew Taylor [États-Unis] ; Regina Jakacki [États-Unis] ; Carol May [États-Unis] ; Denise Howrie [États-Unis] ; Scott Maurer [États-Unis]Source :
- The American journal of hospice & palliative care [ 1938-2715 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- administration et posologie : Analgésiques, Kétamine.
- traitement médicamenteux : Névralgie.
- Adolescent, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Jeune adulte, Mâle, Nourrisson, Résultat thérapeutique, Soins terminaux, Études rétrospectives.
English descriptors
- KwdEn :
- MESH :
- chemical , administration & dosage : Analgesics, Ketamine.
- drug therapy : Neuralgia.
- methods : Terminal Care.
- Adolescent, Child, Child, Preschool, Female, Humans, Infant, Male, Retrospective Studies, Treatment Outcome, Young Adult.
Abstract
Control of neuropathic pain (NP) for children at end of life is challenging. Ketamine improves control of NP, but its use in children is not well described. We describe a retrospective case review of 14 children with terminal prognoses treated with ketamine patient-controlled analgesia (PCA) for management of opioid-refractory NP at the end of life. Median ketamine dose was 0.06 mg/kg/h (range 0.014-0.308 mg/kg/h) with a 0.05 mg/kg (range 0.03-0.5mg/kg) demand dose available every 15 minutes (range 10-60 minutes). All patients noted subjective pain relief with ketamine, and 79% had no adverse effects. Benzodiazepines limited neuropsychiatric side effects. Ketamine treatment arrested dose escalation of opioids in 64% of patients, and 79% were discharged to home hospice. Ketamine PCA is an effective, well-tolerated therapy for opioid-refractory NP in pediatric end-of-life care.
DOI: 10.1177/1049909114543640
PubMed: 25028743
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000086
- to stream PubMed, to step Curation: 000086
- to stream PubMed, to step Checkpoint: 000086
- to stream Ncbi, to step Merge: 002A28
- to stream Ncbi, to step Curation: 002A28
- to stream Ncbi, to step Checkpoint: 002A28
- to stream Main, to step Merge: 000447
- to stream Main, to step Curation: 000447
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Ketamine PCA for treatment of end-of-life neuropathic pain in pediatrics.</title><author><name sortKey="Taylor, Matthew" sort="Taylor, Matthew" uniqKey="Taylor M" first="Matthew" last="Taylor">Matthew Taylor</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Jakacki, Regina" sort="Jakacki, Regina" uniqKey="Jakacki R" first="Regina" last="Jakacki">Regina Jakacki</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA Children's Hospital of Pittsburgh of UPMC Supportive Care Program, Pittsburgh, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA Children's Hospital of Pittsburgh of UPMC Supportive Care Program, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="May, Carol" sort="May, Carol" uniqKey="May C" first="Carol" last="May">Carol May</name><affiliation wicri:level="2"><nlm:affiliation>Children's Hospital of Pittsburgh of UPMC Supportive Care Program, Pittsburgh, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Children's Hospital of Pittsburgh of UPMC Supportive Care Program, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Howrie, Denise" sort="Howrie, Denise" uniqKey="Howrie D" first="Denise" last="Howrie">Denise Howrie</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA University of Pittsburgh School of Pharmacy, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Maurer, Scott" sort="Maurer, Scott" uniqKey="Maurer S" first="Scott" last="Maurer">Scott Maurer</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA Children's Hospital of Pittsburgh of UPMC Supportive Care Program, Pittsburgh, PA, USA Scott.maurer@chp.edu.</nlm:affiliation><country wicri:rule="url">États-Unis</country><wicri:regionArea>Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA Children's Hospital of Pittsburgh of UPMC Supportive Care Program, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25028743</idno><idno type="pmid">25028743</idno><idno type="doi">10.1177/1049909114543640</idno><idno type="wicri:Area/PubMed/Corpus">000086</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000086</idno><idno type="wicri:Area/PubMed/Curation">000086</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000086</idno><idno type="wicri:Area/PubMed/Checkpoint">000086</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000086</idno><idno type="wicri:Area/Ncbi/Merge">002A28</idno><idno type="wicri:Area/Ncbi/Curation">002A28</idno><idno type="wicri:Area/Ncbi/Checkpoint">002A28</idno><idno type="wicri:Area/Main/Merge">000447</idno><idno type="wicri:Area/Main/Curation">000447</idno><idno type="wicri:Area/Main/Exploration">000447</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Ketamine PCA for treatment of end-of-life neuropathic pain in pediatrics.</title><author><name sortKey="Taylor, Matthew" sort="Taylor, Matthew" uniqKey="Taylor M" first="Matthew" last="Taylor">Matthew Taylor</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Jakacki, Regina" sort="Jakacki, Regina" uniqKey="Jakacki R" first="Regina" last="Jakacki">Regina Jakacki</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA Children's Hospital of Pittsburgh of UPMC Supportive Care Program, Pittsburgh, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA Children's Hospital of Pittsburgh of UPMC Supportive Care Program, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="May, Carol" sort="May, Carol" uniqKey="May C" first="Carol" last="May">Carol May</name><affiliation wicri:level="2"><nlm:affiliation>Children's Hospital of Pittsburgh of UPMC Supportive Care Program, Pittsburgh, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Children's Hospital of Pittsburgh of UPMC Supportive Care Program, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Howrie, Denise" sort="Howrie, Denise" uniqKey="Howrie D" first="Denise" last="Howrie">Denise Howrie</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA University of Pittsburgh School of Pharmacy, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Maurer, Scott" sort="Maurer, Scott" uniqKey="Maurer S" first="Scott" last="Maurer">Scott Maurer</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA Children's Hospital of Pittsburgh of UPMC Supportive Care Program, Pittsburgh, PA, USA Scott.maurer@chp.edu.</nlm:affiliation><country wicri:rule="url">États-Unis</country><wicri:regionArea>Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA Children's Hospital of Pittsburgh of UPMC Supportive Care Program, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author></analytic><series><title level="j">The American journal of hospice & palliative care</title><idno type="eISSN">1938-2715</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Analgesics (administration & dosage)</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Humans</term><term>Infant</term><term>Ketamine (administration & dosage)</term><term>Male</term><term>Neuralgia (drug therapy)</term><term>Retrospective Studies</term><term>Terminal Care (methods)</term><term>Treatment Outcome</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Analgésiques (administration et posologie)</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Kétamine (administration et posologie)</term><term>Mâle</term><term>Nourrisson</term><term>Névralgie (traitement médicamenteux)</term><term>Résultat thérapeutique</term><term>Soins terminaux ()</term><term>Études rétrospectives</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Analgesics</term><term>Ketamine</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Analgésiques</term><term>Kétamine</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Neuralgia</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Terminal Care</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Névralgie</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Humans</term><term>Infant</term><term>Male</term><term>Retrospective Studies</term><term>Treatment Outcome</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Nourrisson</term><term>Résultat thérapeutique</term><term>Soins terminaux</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Control of neuropathic pain (NP) for children at end of life is challenging. Ketamine improves control of NP, but its use in children is not well described. We describe a retrospective case review of 14 children with terminal prognoses treated with ketamine patient-controlled analgesia (PCA) for management of opioid-refractory NP at the end of life. Median ketamine dose was 0.06 mg/kg/h (range 0.014-0.308 mg/kg/h) with a 0.05 mg/kg (range 0.03-0.5mg/kg) demand dose available every 15 minutes (range 10-60 minutes). All patients noted subjective pain relief with ketamine, and 79% had no adverse effects. Benzodiazepines limited neuropsychiatric side effects. Ketamine treatment arrested dose escalation of opioids in 64% of patients, and 79% were discharged to home hospice. Ketamine PCA is an effective, well-tolerated therapy for opioid-refractory NP in pediatric end-of-life care.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Pennsylvanie</li></region></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Taylor, Matthew" sort="Taylor, Matthew" uniqKey="Taylor M" first="Matthew" last="Taylor">Matthew Taylor</name></region><name sortKey="Howrie, Denise" sort="Howrie, Denise" uniqKey="Howrie D" first="Denise" last="Howrie">Denise Howrie</name><name sortKey="Jakacki, Regina" sort="Jakacki, Regina" uniqKey="Jakacki R" first="Regina" last="Jakacki">Regina Jakacki</name><name sortKey="Maurer, Scott" sort="Maurer, Scott" uniqKey="Maurer S" first="Scott" last="Maurer">Scott Maurer</name><name sortKey="May, Carol" sort="May, Carol" uniqKey="May C" first="Carol" last="May">Carol May</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Amérique/explor/PittsburghV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000447 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000447 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Amérique
|area= PittsburghV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:25028743
|texte= Ketamine PCA for treatment of end-of-life neuropathic pain in pediatrics.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:25028743" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a PittsburghV1
| This area was generated with Dilib version V0.6.38. |  |